Ernesto Canalis Selected Research

Metabolic Bone Diseases (Osteopenia)

1/2022	Use of antisense oligonucleotides to target Notch3 in skeletal cells.
1/2020	An antibody to Notch3 reverses the skeletal phenotype of lateral meningocele syndrome in male mice.
1/2017	Sustained Notch2 signaling in osteoblasts, but not in osteoclasts, is linked to osteopenia in a mouse model of Hajdu-Cheney syndrome.
1/2017	An Antibody to Notch2 Reverses the Osteopenic Phenotype of Hajdu-Cheney Mutant Male Mice.
8/2013	Notch signaling in osteocytes differentially regulates cancellous and cortical bone remodeling.
4/2012	Conditional inactivation of noggin in the postnatal skeleton causes osteopenia.
1/2012	Gremlin1 is required for skeletal development and postnatal skeletal homeostasis.
8/2010	Connective tissue growth factor is required for skeletal development and postnatal skeletal homeostasis in male mice.
1/2010	Nephroblastoma overexpressed (Nov) inactivation sensitizes osteoblasts to bone morphogenetic protein-2, but nov is dispensable for skeletal homeostasis.
5/2009	Misexpression of CCAAT/enhancer binding protein beta causes osteopenia.

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Ernesto Canalis Research Topics

Disease

23	Osteoporosis 08/2020 - 06/2002
15	Metabolic Bone Diseases (Osteopenia) 01/2022 - 01/2006
15	Bone Resorption 02/2018 - 06/2002
8	Hajdu-Cheney Syndrome (Multicentric Osteolysis) 01/2020 - 06/2013
6	Wilms Tumor (Wilm's Tumor) 02/2011 - 05/2006
3	Acro-Osteolysis (Acroosteolysis) 01/2018 - 01/2016
2	Acromegaly 01/2022 - 08/2019
2	Hypogonadism (Hypergonadotropic Hypogonadism) 01/2022 - 02/2009
2	Inborn Genetic Diseases (Disease, Hereditary) 01/2020 - 05/2008
2	Rare Diseases (Rare Disease) 11/2016 - 01/2016
2	Neoplasms (Cancer) 02/2012 - 07/2008
2	Osteoporotic Fractures 10/2010 - 09/2005
2	Rheumatic Diseases (Rheumatism) 01/2010 - 06/2003
1	COVID-19 08/2020
1	Postmenopausal Osteoporosis 02/2018
1	Weight Gain 11/2015
1	Insulin Resistance 11/2015
1	Fibrosis (Cirrhosis) 04/2014
1	Paralysis (Palsy) 08/2013
1	Alagille Syndrome (Alagille-Watson Syndrome) 06/2013
1	Neuroblastoma 12/2011
1	Breast Neoplasms (Breast Cancer) 10/2010
1	Type 2 Diabetes Mellitus (MODY) 10/2010
1	Prostatic Neoplasms (Prostate Cancer) 10/2010
1	Anorexia Nervosa 08/2008
1	Type B1 Brachydactyly 05/2008
1	Brachydactyly 05/2008
1	Robinow Syndrome 05/2008
1	Autoimmune Diseases (Autoimmune Disease) 06/2003

Drug/Important Bio-Agent (IBA)

13	GlucocorticoidsIBA 01/2018 - 06/2002
10	Proteins (Proteins, Gene)FDA Link 01/2018 - 05/2006
6	Insulin-Like Growth Factor I (IGF-1)IBA 08/2019 - 01/2006
6	Connective Tissue Growth FactorIBA 04/2014 - 05/2006
6	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 04/2012 - 11/2007
5	LigandsIBA 01/2020 - 09/2005
4	Notch ReceptorsIBA 01/2020 - 02/2012
4	AntibodiesIBA 01/2020 - 09/2010
3	MineralsIBA 01/2017 - 12/2002
3	Anabolic AgentsIBA 12/2014 - 11/2009
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 09/2010 - 11/2009
3	Diphosphonates (Bisphosphonates)IBA 02/2009 - 06/2002
2	Antisense OligonucleotidesIBA 01/2022 - 01/2020
2	Parathyroid Hormone (Parathormone)IBA 02/2018 - 09/2010
2	Teriparatide (Parathar)FDA Link 02/2018 - 02/2009
2	RANK LigandIBA 01/2018 - 06/2002
2	OsteoprotegerinIBA 01/2016 - 06/2002
2	AndrogensIBA 10/2010 - 02/2009
2	Cysteine (L-Cysteine)FDA Link 08/2010 - 05/2006
2	Matrix Metalloproteinase 13IBA 02/2004 - 06/2002
1	Hormones (Hormone)IBA 01/2022
1	Insulin-Like Growth Factor Binding ProteinsIBA 01/2022
1	CalciumIBA 08/2020
1	Parathyroid Hormone-Related ProteinIBA 02/2018
1	abaloparatideIBA 02/2018
1	romosozumabIBA 02/2018
1	Threonine (L-Threonine)FDA Link 01/2017
1	Proline (L-Proline)FDA Link 01/2017
1	Serine (L-Serine)FDA Link 01/2017
1	Glutamic Acid (Glutamate)FDA Link 01/2017
1	Notch2 ReceptorIBA 11/2016
1	Denosumab FDA Link 11/2016
1	Amino Acids FDA Link 01/2016
1	Insulin-Like Growth Factor Binding Protein 2IBA 11/2015
1	CytokinesIBA 04/2014
1	Bone Density Conservation AgentsIBA 10/2013
1	Type A Botulinum Toxins (Botox)FDA Link 08/2013
1	Interleukin-6 (Interleukin 6)IBA 07/2013
1	Peptides (Polypeptides)IBA 04/2011
1	Aromatase InhibitorsIBA 10/2010
1	Pharmaceutical PreparationsIBA 10/2010
1	Thyroxine (Levothyroxine)FDA LinkGeneric 10/2010
1	CCAAT-Enhancer-Binding Protein-betaIBA 05/2009
1	Estrogens (Estrogen)FDA Link 02/2009
1	beta CateninIBA 08/2008
1	Glycoproteins (Glycoprotein)IBA 07/2008
1	Phosphotransferases (Kinase)IBA 07/2008
1	bis(diazo)benzidine (BDB)IBA 05/2008
1	Transforming Growth Factor beta (TGF-beta)IBA 11/2007
1	OsteocalcinIBA 11/2007
1	Transforming Growth Factors (Transforming Growth Factor)IBA 11/2007
1	CCAAT-Enhancer-Binding ProteinsIBA 03/2007
1	CollagenIBA 02/2004

Therapy/Procedure

12	Therapeutics 01/2022 - 05/2006